Glutationa S-transferase M1 (GSTM-1): distribuição étnica e relação com câncer
نویسندگان
چکیده
منابع مشابه
Glutathione S-transferase GSTM 1, null genotype may be associated with susceptibility to age-related cataract.
BACKGROUND Age-related cataract (ARC) is the leading cause of visual disability and reversible blindness all over the world. The different expressions of GST isozymes among animals may explain the variations in the cataract formation caused by oxidative stress. OBJECTIVES In this study, we evaluated the distribution of GST gene polymorphisms in ARC patients and the possible associations betwe...
متن کامل1 Glutathione - S - Transferase ( GST ) P 1 , GSTM 1 , Exercise , Ozone and Asthma Incidence in School Children
Background: Because asthma has been associated with exercise and ozone exposure, an association likely mediated by oxidative stress, we hypothesized that GSTP1, GSTM1, exercise and ozone exposure have interrelated effects on asthma pathogenesis. Methods: We examined associations of the well characterized null variant of GSTM1 and four SNPs that characterized common variation in the GSTP1 locus ...
متن کاملEstrogen receptor 1, glutathione S-transferase P1, glutathione S-transferase M1, and glutathione S-transferase T1 genes with dysmenorrhea in Korean female adolescents.
BACKGROUND Dysmenorrhea is the most common gynecologic complaint among adolescent females. We investigated the association between genetic polymorphisms and dysmenorrhea. METHODS A total of 202 postmenarcheal Korean female adolescents 16-17 yr old participated in this study. Genotyping for glutathione S-transferase mu 1 (GSTM1), glutathione S-transferase theta 1 (GSTT1), glutathione S-transfe...
متن کاملThe glutathione S-transferase M1 genotype in ovarian cancer.
Glutathione S-transferase mu-1 (GSTM1) is a polymorphic member of the mu class gene family of the glutathione S-transferases. Individuals who are GSTM1 null have increased susceptibility to lung and colon cancer. We hypothesized that: (a) GSTM1 null individuals might also be at increased risk for development of ovarian cancer; and (b) the GSTM1 genotype would influence response to chemotherapy....
متن کاملGlutathione S Transferase M1 Polymorphism in Extrahepatic Biliary Atresia
Background: Extrahepatic biliary atresia (EHBA) is a chronic progressive obstructive cholangiopathy of infancy of unknown aetiology. Pathology of bile duct damage involves unanimously neutrophil elastase, variable degrees of fibrosis, and variable CD14+ monocytes intensity staining in the presence of defective p53 and glutathione S transferases Pi class (GST Pi). GST is a super family responsib...
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ژورنال
عنوان ژورنال: Semina: Ciências Biológicas e da Saúde
سال: 2001
ISSN: 1679-0367,1676-5435
DOI: 10.5433/1679-0367.2001v22n1p3